Science Inspiring Our Investigations:

• Mediterranean Diet is Associated with Enhanced Bone Health: Malmir, H., Saneei, P., Larijani, B. et al, Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies, Eur J Nutr (2018) 57: 2147; https://doi.org/10.1007/s00394-017-1490-3

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• Lipids can modulate bone:  Bab, et al, Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family, British Journal of Pharmacology (2011) 163 1441–1446 1441; https://doi.org/10.1111/j.1476-5381.2011.01474.x

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• OS  is an endogenous lipidomic (in food and serum) and effects bone remodeling and mass: Smoum, et al, Oleoyl Serine, an endogenous N-acyl amide, modulates bone remodeling and mass, PNAS (October 12, 2010) vol. 107 no. 41 pp 17710–17715; www.pnas.org/cgi/doi/10.1073/pnas.0912479107

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• OS is found in food (including olive oil): Bradshaw, et al, Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine, J Basic Clin Physiol Pharmacol 2016; 27(3): 247–252; https://doi.org/10.1515/jbcpp-2015-0104

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• PWS Magel 2 mouse model shows prevention of bone loss: Baraghithy, et al, Magel2 Modulates Bone Remodeling and Mass in Prader-Willi Syndrome by Affecting Oleoyl Serine Levels and Activity, Journal of Bone and Mineral Research, Vol. 34, No. 1 (October 2018), pp 93-105; https://doi.org/10.1002/jbmr.3591

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• Menopause mouse model shows rescue of loss bone: Baraghithy, et al, HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity, Molecules (October 16, 2019), 24,  3719; http://dx.doi.org/10.3390/molecules24203719