Relevant Publications

SCIENCE INSPIRING OUR PROGRAMS

Mediterranean Diet

is Associated with Enhanced Bone Health

Malmir, H., Saneei, P., Larijani, B. et al, Adherence to Mediterranean diet in relation to bone mineral density and risk of fracture: a systematic review and meta-analysis of observational studies, Eur J Nutr (2018) 57: 2147

Skeletal Lipids

can Modulate Bone

Bab, et al, Skeletal lipidomics: regulation of bone metabolism by fatty acid amide family, British Journal of Pharmacology (2011) 163 1441–1446 1441

is an endogenous compound (found in olive oil and our bodies) and effects bone mineral density

Smoum, et al, Oleoyl Serine, an endogenous N-acyl amide, modulates bone remodeling and mass, PNAS (October 12, 2010) vol. 107 no. 41 pp 17710–17715

is found in food (including olive oil)

Bradshaw, et al, Levels of bioactive lipids in cooking oils: olive oil is the richest source of oleoyl serine, J Basic Clin Physiol Pharmacol 2016; 27(3): 247–252

PWS Magel 2

mouse model shows prevention of bone loss

Baraghithy, et al, Magel2 Modulates Bone Remodeling and Mass in Prader-Willi Syndrome by Affecting Oleoyl Serine Levels and Activity, Journal of Bone and Mineral Research, Vol. 34, No. 1 (October 2018), pp 93-105

Menopause mouse model

shows rescue of loss bone

Baraghithy, et al, HU-671, a Novel Oleoyl Serine Derivative, Exhibits Enhanced Efficacy in Reversing Ovariectomy-Induced Osteoporosis and Bone Marrow Adiposity, Molecules (October 16, 2019), 24, 3719